Pharmacology

Suven Life Sciences offers wide range of services for evaluating medications intended for various central nervous system disorders.

Animal models of cognition

  • Object recognition task Ė Delay or scopolamine induced deficits
  • Water maze Ė Scopolamine induced deficits
  • Radial arm maze
  • Social recognition task
  • Contextual fear conditioning
  • Cerebral blood flow

Animal models of psychosis

  • Prepulse inhibition
  • MK-801 or Amphetamine antagonism
  • Conditioned avoidance
  • Dominant submissive assay
  • Resident intruder task

Animal models of anxiety

  • Elevated plus maze
  • Hole board
  • Vogel conflict
  • Novelty induced hypophagia

Animal models of depression

  • Forced swim / Tail suspension test
  • Dominant submissive assay
  • Differential reinforcement at low rates-72s

Animal models of pain

  • Acetic acid induced writhing/ Formalin induced nociception/ Hot plate
  • Complete Freundís adjuvant / Chemotherapy / Streptozotocin/ Capsaicin / Mono iodoacetate / Reserpine induced pain
  • Spinal nerve ligation / Chronic constriction injury/ Partial sciatic nerve ligation
  • Medial meniscal tear
  • Chronic post-ischemia pain
  • Spontaneous burrowing behavior
  • In vivo electrophysiology

Other models

  • MPTP induced Parkinsonís disease
  • Erectile dysfunction

In Vivo Receptor Occupancy Assays

Suven offers tracer development and target engagement services using hot /cold tracers in selection of better clinical candidate and projecting clinical doses.

  • Adenosine: A2A
  • Nicotinic acetylcholine receptors: α4β2 and α7
  • Cannabinoid CB1
  • Dopamine D1 & D2
  • GABAA
  • Histamine: H3
  • Serotonin: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT6, and 5-HT2C
  • Phosphodiesterase 10
  • Serotonin transporter (SERT)/Dopamine transporter (DAT)/Norepinephrine transporter (NET)
  • Sigma-1
  • Monoamine oxidase-A and B
  • Novel tracers for non-validated targets
  • In Vivo Receptor Occupancy AssaysView PDF

Microdialysis, Neurochemistry and Biomarker

Suven provides in vivo microdialysis and neurochemistry services to study the mechanism of action, efficacy and side-effect profile of centrally-acting drugs.

  • Acetylcholine
  • Histamine
  • Glutamate, GABA and Glycine
  • Dopamine, Norepinephrine, Serotonin, and its metabolites
  • Peptides (Substance-P and PGE2)
  • Beta amyloid (1-40, 1-42), Soluble APPa
  • Corticosterone
  • Interleukins
  • Inositol 1- phosphate
  • Prolactin
  • Prostaglandin E2
  • Substance P
  • tele- methylhistamine
  • Microdialysis, Neurochemistry and BiomarkerView PDF

Electroencephalography (EEG)

Suven has large spectrum of EEG assays with most advanced infrastructure using implantable telemetry (DSI, USA) to support early stage of drug discovery.

  • Sleep/ wake activity
  • Temperature and wake promoting activity
  • Total EEG power
  • Power analysis in frequency bands
  • Assessment for seizure evaluation potential
  • Assessment of cognitive biomarkers (Theta and Gamma Activity)
  • Simultaneous power analysis in animal performing behavioral task
  • Orexin-SAP induced chemical lesion model for narcolepsy
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