Suven Life Sciences Limited

Suven Life Sciences Limited is a Bio-pharmaceutical company in existence since 1989 based at Hyderabad, India. Suven Life Sciences is committed to i) Discovery & development of New Chemical Entities (NCEs) for CNS disorders ii) Research Collaborative Projects (CRP) with major Pharmaceutical companies & iii) Providing niche scientific services through Drug Discovery Research Services. Suven has all its state-of-art facilities with highly qualified & experienced Scientists and Managers.

Suven Life Sciences offers Drug Discovery Research Services to global Pharma and Biotech companies, specializing in Physicochemical properties;  screening (Receptors/Enzymes); Assay development;  and  Drug metabolism & Pharmacokinetics in rodents, non-rodents; Brain penetration; Microdialysis; Receptor Occupancy; CNS Pharmacology; Safety Pharmacology;  and In-vivo rodent Toxicology; Histopathology; Clinical Pathology and Bioanalysis.

Services

In-vitro Screening and Molecular Biology

Suven Life Sciences offers comprehensive range of In-vitro services and Screening programs to meet the needs of the pharmaceutical and biotechnology industries around the world for increasing the productivity of drug discovery and development programs.

We have developed fully characterized and validated screening assays include:

  • In-vitro screening assays
  • Electrophysiology assays
  • In-vitro permeability assays
  • In-vitro cytotoxicity and phospholipidosis assays

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Drug Metabolism and Pharmacokinetics

Suven Life Sciences is dedicated to provide quality PK/TK/ADME services to assist pharmaceutical and biotechnology companies in preclinical development and candidate selection. We have established various  (all species, hepatocellular, microsomal, supersomal, plasma, etc) and  (Rodent - mice, rat, rabbit, guinea pig & Non Rodent - Beagle dogs) pharmacokinetics and metabolism assays.

 Pharmacokinetic Assays

  • Single Dose PK
  • Bioavailability
  • Intravenous Cassette dose
  • Brain Penetration Study
  • Reactive Metabolite Identification
  • CSF Pharmacokinetic Study  
  • Free Drug Estimation in brain dialysate fluids (Microdialysis)
  • Bioanalytical Method Development and Partial Validation.

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 ADME

  • Solubility of Test Item at pH 7.4
  • Metabolic Stability
  • Metabolite Identification
  • CYP Inhibition
  • Protein Binding
  • Brain in Beaker

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Pharmacology

Suven Life Sciences has established various safety and efficacy pharmacology (CNS: Cognition, Depression, Anxiety, Obesity and Pain) models to screen and/or develop lead compounds. We utilize our scientific expertise to validate new drug targets or to develop novel models for assessing client-specific targeting needs.  

Safety Pharmacology

  • General Safety Assays
  • CNS Safety Assays
  • GI Safety Assays
  • Respiratory Safety Assays

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CNS Pharmacology (Cognition, Depression and Pain & Obesity)

  • Addiction Assay
  • Pain Assays
  • Anxiety Assays
  • Cognition Assays
  • Depression Assays
  • Schizophrenia Assays
  • General Behavioral Assays
  • Brain Microdialysis Assays (Click here)
  • Receptor Occupancy Studies

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Toxicology

Suven Life Sciences has many years of extensive experience in the field of toxicology. We offer exploratory and discovery rodent (rat and mice) toxicity evaluation (4, 7, 14 and 28 days) including histopathology, clinical pathology and genotox to assist pharmaceutical and biotechnology companies in preclinical development and candidate selection.

Discovery Tox Express:

Tox studies are conducted on NCEs in the early stage of drug discovery. The Tox data are generated in extremely rapid timeline, at the same time with highest quality and scientific integrity for decision making of molecule progression.

Services

Toxicology

  • Acute Toxicity studies in rodent
  • Dose range finding ( DRF ) studies in rodent
  • Maximum Tolerated dose ( MTD) studies in rodent
  • 4 / 7 / 14 / 28 days repeated dose toxicity studies in rodent
  • Toxicokinetic studies in rodent

Genotoxicity

  • Bacterial Reverse Mutation Assay (Ames assay- Mini / Standard)
  • In Vitro Mammalian Chromosome Aberration Test in Cultured Human Peripheral Blood Lymphocytes / CHO cell line
  • In Vivo Mammalian bone marrow Chromosomal Aberration Test
  • In Vitro Micronucleus Test
  • In Vivo Mammalian Erythrocyte Micronucleus Test

Histopathology

  • Tissue processing and slide preparation
  • Routine (H & E) and special staining techniques
  • Microscopic evaluation of slides by experienced Veterinary Pathologists
  • In Vitro Micronucleus Test

Clinical Pathology

  • Hematology
  • Coagulation analysis
  • Clinical chemistry
  • Urinalysis

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Bioanalysis

Suven Life Sciences offers a seamless process for your pharmacokinetic and toxicokinetic evaluations, one that begins with formulation and dosing, followed by sample collection and bioanalytical mehod development, validation and ending with data analysis and report generation. Quantitation of your compound in biological matrices such as blood, plasma, serum, urine, and tissues is usually accomplished using LC-MS/MS. Access to scientific expertise and technical support for data interpretation. All bioanalytical services are conducted according relevant regulatory guidelines.

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